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Adult Diabetics in the US Have Improved Control of Total Cholesterol Levels, But Not of Blood Glucose Levels or Blood Pressure

Journal of the American Medical Association (JAMA)

01/20/2004
By Joene Hendry
 


There is a significant improvement in the control of total cholesterol levels, but not in the control of blood glucose levels and blood pressure, among adults with previously diagnosed diabetes who participated in the Third National Health and Nutrition Examination Survey (NHANES III) compared with those who participated in NHANES 1999-2000.

"Progress in improving risk factors for vascular disease among individuals with diagnosed diabetes in the United States over nearly a decade has been modest," writes Catherine C. Cowie, PhD, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, and colleagues.

The researchers analysed data from 1,265 adult participants in NHANES III, conducted in 1988 through 1994, with those of 441 adult participants in NHANES 1999-2000, to assess trends in the control of vascular disease risk factors in diabetics according to target levels of glycosylated haemoglobin, blood pressure, and total serum cholesterol established by the American Diabetes Association.

The 2 studies revealed similar age-standardised prevalence of previously diagnosed diabetes - 5.4% in NHANES III and 6.1% in NHANES 1999-2000 - and, while participants with diabetes were similar in age and sex, there was a trend toward younger age at diagnosis - 50.7 years in NHANES III compared with 46.7 years in NHANES 1999-2000. However, mean body mass index (BMI) increased significantly from 29.9 to 32.3 and the percentage of those with diagnosed diabetes and BMI greater than or at 30 increased from 41.6% to 54.6% from NHANES III to NHANES 1999-2000.

The 2 studies showed similar levels of mean glycosylated haemoglobin - 7.6 and 7.8, respectively. However, only 37.0% of the adults in the more recent study had glycosylated haemoglobin levels at the American Diabetes Association goal of less than 7%.

In the earlier study, 29.0% of the participants had the recommended blood pressure of less than 130 mm Hg systolic and 80 mm Hg diastolic. This percentage rose to 35.8% of the later study population.

Overall levels of total serum cholesterol decreased from a mean of 222.8 mg/dL to 208.9 mg/dL from the earlier to the later study. However, the later study revealed that 50.0% of men and 53.8% of women still had total serum cholesterol levels at 200 mg/dL or higher.

In the earlier NHANES III, 5.2% of the adults with diabetes achieved currently recommended goals of glycosylated haemoglobin level, blood pressure, and total serum cholesterol. By NHANES 1999-2000 this percentage rose to only 7.3%, which indicates only a small percentage of US adults diagnosed with diabetes are achieving currently recommended levels of control.

JAMA 2004;291:335-342.